Seizure Generator Location and Antiepiletic Drug Efficacy


Childhood absence epilepsy is the most common pediatric epilepsy syndrome and up to 50% of the patients will fail the best initial drug treatment. Although absence seizures have been classically categorized as “generalized”, the brain structures responsible for generating the seizures are poorly understood. Response to initial drug treatment may be dependent upon whether the seizure begins on the surface of the brain (cortex) or in deeper structures (thalamus). The overall goal of this project is to use state of the art imaging techniques to compare the areas of seizure onset in children with medication responsive and non-responsive absence epilepsy. This information will then be used to review the initial routine electroencephalograms (EEGs) for patterns that could predict the initial response to medication treatment. Better understanding of the specific differences between easily treated and difficult to control seizures will lead to reduced seizure burden and medication side effects by early identification of children who would be most appropriate candidates for more aggressive therapies and ultimately carry out CURE’s mission of “no seizures, no side effects”.